Effects of low-power laser irradiation on the threshold of electrically induced paroxysmal discharge in rabbit hippocampus CA1 |
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| Authors: | Shinichi Kogure Satoshi Takahashi Nobuaki Saito Kazuya Kozuka Yoshiki Matsuda |
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| Affiliation: | 1. Department of Bioinformatics, Faculty of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, 192-8577, Japan
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| Abstract: | In acute experiments using adult rabbits, we measured the paroxysmal discharge threshold (PADT) elicited by stimulation to the apical dendritic layer of the hippocampal CA1 region before and after low-power laser irradiation. Nd:YVO4 laser irradiation (wavelength: 532 nm) was introduced into the same region as the stimulation site. The average PADT was 247?±?13 μA (n?=?18) before laser irradiation, while after 5-min laser irradiation with 50, 75, and 100 mW, PADT was 333?±?40 (n?=?4), 353?±?33 (n?=?4) and 367?±?27 μA (n?=?6), respectively. The latter two increments were statistically significant compared to the control (p? p?n?=?9) and 480?±?60 μA (n?=?11; p?
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