脑电图在小鼠氧惊厥研究中的应用

目的 观察小鼠氧惊厥及惊厥后脑电图的改变。方法 小鼠头部预先埋置电极，进行舱内高压氧（HBO）暴露，动态观察记录氧惊厥小鼠脑电改变以及暴露后脑电恢复情况。结果 小鼠埋置电极3～5d后脑电改变恢复正常，舱内HBO暴露致氧惊厥时脑电图发生类似癫痫大发作时的痫波变化，并在氧暴露撤离后7d左右脑电图改变恢复正常。结论 脑电图记录在小鼠氧惊厥研究中是一种可行、客观和稳定的方法。

Application of EEG in the research of oxygen-induced convulsion in mice

Objective To observe the changes of EEG in mice exposed to hyperbaric oxygen. Methods Embedded electrodes in calvaria of mice by surgery beforehand, the mice were exposed to hyperbaric oxygen in chamber. The changes of brain waves of mice in hyperbaric chamber and the succedent recovery were recorded by EEG. Results After electrodes being embedded, mice's EEGs may would become normal after 3 to 5 days. When the mice were exposed to hyperbaric oxygen ( 5 ATA ) to induce convulsions, the EEGs presented epilepsy-like changes and the changes dispeared on the 7th day following hyperbaric oxygen with drawing. Conclusions EEG recording is a practical, objective and stable method in the research of oxygen-induced convulsion in mice.