氯诺昔康的不良反应及其合理使用的回顾性调查

目的：了解住院患服用氯诺昔康(可塞风)的疗效、药物不良反应，促进临床合理使用。方法：回顾性观察使用氯诺昔康的29例住院患，评价其止痛效果、药物不良反应发生及合理用药。结果：29例疼痛患使用氯诺昔康后止痛效果确切，疼痛缓解率为100％。发生药物不良反应2例，药物不良反应发生率为6．90％；药物不良反应的发生与年龄大、合并用药不合理有关。不合理用药9例，发生率为31．03％，主要问题为用法、用量不当及合并用药不当。结论：氯诺昔康在临床上应用于镇痛，疗效确切，但要注意合理用药，避免不当的合并用药。

A Retrospective Study of Adverse Drug Reaction and Rational Use of Lornoxicam

Objective:To study the rate of adverse drug reaction(ADR) and the rational use of lornoxicam among in-patients.Methods:All in-patients treated with lornoxicam in department of oncology in our hospital were retrospectively observed.Results:The overall efficacy of lornoxicam on pain lysis was 100%. Of 29 patients 4 ADR cases were found with a ADR rate was 6.90%. The ADR occurrence was related to older age and irrational drug use. 9 cases(31.03%) were related with irrational drug use, mainly irrational drug regimen and irrational drug combination. Conclusion:Lornoxicam is safe in clinical use, but attention should be paid on drug adverse reaction and rational use, particularly in the irrational drug combination.