卡氮芥对肺癌中枢神经系统转移的预防作用及毒性探讨

目的探讨卡氮芥对肺癌中枢神经系统转移的预防作用以及卡氮芥的毒付作用。方法对13例肺癌患者在常规化疗的基础上，加用3次卡氮芥，并设立对照组，观察其脑转移的发生率，毒副反应的发生率。结果使用卡氮芥的治疗组脑转移率明显下降，但骨髓抑制和疲劳感的毒副作用发生率明显增高。结论肺癌患者在常规治疗的基础上，加用卡氮芥可降低脑转移的发生率，因毒副反应较大，临床应谨慎用药。

The study of carmustine role in the prevention of CNS metastasis of lung cancer and its adverse reactions

Objective To investigate earmustine role in the prevention of CNS metastasis of lung cancer and its adverse reactions. Methods In 13 patients with lung cancer on the basis of conventional chemotherapy, plus earmustine three times, and also establish a control group. The incidence of brain metastases and the incidence of adverse reaction were observed. Results Brain metastases rates were lower in the observation group. However, the incidence of adverse effects bone marrow depression and fatigue were significantly higher. Conclusion In patients with lung cancer on the basis of conventional therapy, plus earmustine can reduce the incidence of brain metastases. Because of larger adverse reactions, clinical use should be cautious.