| 脉络膜新生血管患者房水中血管内皮生长因子和色素上皮衍生因子的浓度 |
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| 引用本文： | 童剑萍,沈晔,陈伟民,林顺潮,彭智培.脉络膜新生血管患者房水中血管内皮生长因子和色素上皮衍生因子的浓度[J].浙江大学学报(医学版),2006,35(3):311-314. |
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| 作者姓名： | 童剑萍 沈晔 陈伟民 林顺潮 彭智培 |
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| 作者单位： | 1. 浙江大学医学院,附属第一医院浙益眼科中心,浙江,杭州,310003
2. 香港中文大学眼科及视觉科学系,香港 |
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| 摘 要： | 目的:研究血管内皮生长因子(VEGF)和色素上皮衍生因子(PEDF)在活动性脉络膜新生血管膜(CNV)患者房水中的表达。方法:应用酶联免疫吸附测定法对32例活动性CNV患者和10例白内障患者(对照组)的房水标本进行VEGF和PEDF检测。结果:CNV患者房水中的VEGF为(523.0±273.7)pg/m l,PEDF为(16.58.±13.11)ng/m l;对照组患者房水中的VEGF为(108.3±72.3)pg/m l,PEDF为(0.35±0.57)ng/m l。两组间的VEGF和PEDF均有显著性差异(均P=0.000)。结论:活动性CNV患者房水中VEGF和PEDF增高,可能与脉络膜新生血管的形成有关。
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| 关 键 词： | 血管内皮生长因子A/生物合成 色素上皮 眼 眼房水/化学 脉络膜新生血管化/代谢 新生血管化 病理性 酶联免疫吸附测定 |
| 文章编号： | 1008-9292（2006）03-0311-04 |
| 收稿时间： | 2005-03-03 |
| 修稿时间： | 2006-03-20 |
Vascular endothelial growth factor and pigment epithelium-derived factor in aqueous humor of patients with choroidal neovascularization |
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| TONG Jian-ping.Vascular endothelial growth factor and pigment epithelium-derived factor in aqueous humor of patients with choroidal neovascularization[J].Journal of Zhejiang University(Medical Sciences),2006,35(3):311-314. |
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| Authors: | TONG Jian-ping |
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| Institution: | Zheyi Eye Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. |
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| Abstract: | Objective: To detect the levels of vascular endothelial growth factor(VEGF) and pigment epithelium-derived factor(PEDF) in aqueous humor of patients with active choroidal neovascularization(CNV).Methods: Aqueous humor samples were obtained from 32 patients with active CNV.The concentrations of VEGF and PEDF in aqueous humor were measured by enzyme linked immunosorbent assay(ELISA) for quantitative analysis.VEGF and PEDF in 10 samples of aqueous humor from patients with cataract were also detected by the same methods as control.Results: The mean VEGF and PEDF concentrations in aqueous humor of active CNV patients were higher than those in the control group(P=0.000).Conclusion: The patients with active CNV exhibit significantly higher VEGF and PEDF levels than those in control,indicating that VEGF along with PEDF may modulate the formation of CNV. |
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| Keywords: | Vascular endothelial growth factor A/biosyn Pigment epithelium of eye Aqueous humor/chem Choroidal neovascularization/metabol Neovascularization pathologic Enzyme-linked immunosorbent assay |
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