囊性肺纤维化同种异体肺移植1例报告

为1例17岁女性严重囊性肺纤维化患者行右侧单肺移植，术中未用体外循环，供肺采用冷UW液灌注，冷缺血时间280min。术后18h停用呼吸机，第4天下地活动。术后免疫抑制剂选用甲基强的松龙冲击治疗后再用“新三联”(FK506，骁悉，强的松)维持后续治疗。患者术后恢复顺利，复查肺功能基本正常，动脉血气分析显示较术前明显改善。术后第1个月未出现严重排异反应。目前存活状况良好。

Lung transplantation for treatment of pulmonary cystic fibrosis: report of one case]

A right single lung transplantation was performed in a 17-year-old female patient with end-stage cystoid pulmonary fibrosis and without cardiopulmonary bypass in June 2003. The donor lung was perfused with cold UW solution with a cold ischemic time of 280 min. The patient weaned from ventilator on the next day of operation (18 h later) and was able to walk at the fourth day postoperatively. Immunosuppression included methylprednisolone used before FK 506, mycophenolate mofetil and prednisone dosed after operation. The patient remains well a month after operation with significant improvement of the lung function and enjoys normal life.