| 荧光原位杂交在膀胱尿路上皮癌中的应用 |
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| 引用本文： | 肖兰,杨继洲,康照利.荧光原位杂交在膀胱尿路上皮癌中的应用[J].肿瘤防治研究,2011,38(3):302-304. |
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| 作者姓名： | 肖兰 杨继洲 康照利 |
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| 作者单位： | 1.432100湖北孝感，孝感市中心医院病理科，2.骨外科 |
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| 基金项目： | 湖北省科技厅研究与开发计划资助项目(2008BCZ003) |
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| 摘 要： | 目的探讨3,7,17号染色体及9p21(p16基因)组合探针在监测膀胱尿路上皮癌术后复发及诊断膀胱尿路上皮癌的应用价值。方法利用荧光原位杂交（FISH）检测膀胱尿路上皮癌患者的尿脱落细胞及组织切片中3,7,17号染色体及9p21组合的畸变情况。结果FISH监测膀胱尿路上皮癌术后复发的敏感度为87.50%；术前FISH阳性的患者术后更易复发；FISH诊断膀胱尿路上皮癌的阳性率为78.85％。结论利用FISH检测尿脱落细胞中3,7,17号染色体及9p21组合的畸变能有效辅助监测膀胱尿路上皮癌术后复发；并可能在一定程度上预测术后复发；同时利用FISH检测组织切片中3,7,17号染色体及9p21组合的畸变也能有效辅助膀胱尿路上皮癌的诊断。
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| 关 键 词： | 关键词：荧光原位杂交 膀胱尿路上皮癌 染色体畸变 |
| 收稿时间： | 2010-01-14; |
Detection of Uroepithelium Carcinoma of Bladder by Fluorescence in situ Hybridization |
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| XIAO Lan,YANG Ji-zhou,KANG Zhao-li.Detection of Uroepithelium Carcinoma of Bladder by Fluorescence in situ Hybridization[J].Cancer Research on Prevention and Treatment,2011,38(3):302-304. |
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| Authors: | XIAO Lan YANG Ji-zhou KANG Zhao-li |
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| Institution: | 1. Department of Pathology，The Central Hospital in Xiaogan，Xiaogan 432100，China,2. Department of Bone Surgery |
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| Abstract: | Objective To explore of clinical application of chromosome 3,7,17 and 9p21 combination probe to monitor urothelial carcinoma recurrence and to diagnose urothelial carcinoma.Methods Detect the urin-cells from the urina sanguinis and the tissue sections of patient who trouble epithelioma of bladder by FISH.Results The sensibility to monitor the recurrence of epithelioma of bladder is 87.50% and the masculine rate is 78.85% to diagnose epithelioma of bladder by FISH.The patient who was positive by FISH to be m... |
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| Keywords: | Fluorescence in situ hybridisation Uroepithelium cancer of bladder Chromosomal aberration |
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