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| 姜黄素对人鼻咽癌CNE-2Z细胞增殖及 凋亡的影响 | |
| 引用本文： | 范德生,甄蕾,孙宁.姜黄素对人鼻咽癌CNE-2Z细胞增殖及 凋亡的影响[J].肿瘤防治研究,2011,38(3):254-256. |
| 作者姓名： | 范德生 甄蕾 孙宁 |
| 作者单位： | 1. 上海中医药大学附属曙光医院病理科,上海,200021 2. 同济大学医学院 3. 广东医学院病理学教研室 |
| 基金项目： | 广东省教育厅自然科学研究基金资助项目(GK0404) |
| 摘 要： | 目的探讨姜黄素对人鼻咽癌CNE-2Z细胞增殖及凋亡的影响及其相关的分子机制。方法体外培养的 CNE-2Z细胞经不同剂量姜黄素处理后，用MTT法观察对细胞增殖的影响，流式细胞术检测细胞周期和凋亡 率的改变，Western blot检测姜黄素处理后相关蛋白Bcl-2、Bax表达水平的变化。结果姜黄素对CNE-2Z细 胞的生长和增殖都具有一定程度的抑制作用，阻断细胞于S期和G2/M期。姜黄素处理后CNE-2Z细胞凋亡抑 制基因Bcl-2蛋白表达减少,同时促凋亡基因Bax蛋白表达增加。 结论姜黄素可抑制CNE-2Z细胞增殖并促进 其凋亡。 |
| 关 键 词： | 关键词：姜黄素 鼻咽癌 增殖 凋亡 Bcl-2 Bax |
| 收稿时间： | 2010-02-15; |
Effect of Curcumin on Proliferation and Apoptosis of Human Nasopharyngeal Carcinoma CNE-2Z Cells |
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| FAN De-sheng,ZHEN Lei,SUN Ning.Effect of Curcumin on Proliferation and Apoptosis of Human Nasopharyngeal Carcinoma CNE-2Z Cells[J].Cancer Research on Prevention and Treatment,2011,38(3):254-256. | |
| Authors: | FAN De-sheng ZHEN Lei SUN Ning |
| Institution: | FAN De-sheng1,ZHEN Lei2,SUN Ning3 1.Department of Pathology,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China,2.College of Medicine,Tongji University,3.Department of Pathology,Guangdong Medical College |
| Abstract: | Objective To study the effects of Curcumin on proliferation and apoptosis of human nasopharyngeal carcinoma cell CNE-2Z and its possible mechanism.Methods After treatment with Curcumin at various concentrations,the proliferative inhibition of CNE-2Z was observed by MTT assay.The cell cycle influence and cell apoptosis rate were detected by flow cytometry.The expression of Bcl-2 and Bax were detected by Western blot.Results Curcumin could inhibit the proliferation of human nasopharyngeal carcinoma cells CNE-... |
| Keywords: | Curcumin Nasopharyngeal carcinoma Proliferation Apoptosis Bcl-2 Bax |
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