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| 香菇多糖改善衰老小鼠学习记忆能力的抗氧化机制 | |
| 引用本文： | 逯爱梅,于天贵,李文杰,辛晓明. 香菇多糖改善衰老小鼠学习记忆能力的抗氧化机制[J]. 中国老年学杂志, 2011, 31(4) |
| 作者姓名： | 逯爱梅 于天贵 李文杰 辛晓明 |
| 作者单位： | 1. 济南市传染病医院,山东,济南,250021 2. 山东医学高等专科学校 3. 泰山医学院 |
| 基金项目： | 山东省自然基金课题(No.2007C063); 山东省教育厅科研课题(No.J07YD11) |
| 摘 要： | 目的探讨香菇多糖(LNT)改善衰老小鼠学习记忆能力的抗氧化机制。方法建立D-半乳糖(D-gal)致小鼠学习记忆障碍模型,跳台实验检测其学习记忆能力,检测大脑超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量和谷胱甘肽过氧化物酶(GSH-Px)活性,观察小鼠灌胃LNT后上述指标变化。结果与正常对照组小鼠相比,D-gal模型组小鼠错误次数明显增加,潜伏期明显缩短,学习记忆能力明显下降。LNT在30和60 mg.kg-1.d-1两个剂量时,可使小鼠脑组织中SOD和GSH-Px活性明显提高,与小鼠表现的错误次数成负相关,而与潜伏期成正相关;同时可使脑组织中MDA含量明显降低,与小鼠表现的错误次数成正相关,而与潜伏期成负相关。结论 LNT可改善D-gal致学习记忆障碍小鼠的学习记忆能力,其机制可能与其抗氧化作用有关。 |
| 关 键 词： | 香菇多糖 D-半乳糖 学习记忆 抗氧化 |
Antioxidant mechanisms of the improving effects of lentinan on learning and memory function in aging mice |
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| LU Ai-Mei,YU Tian-Gui,LI Wen-Jie,et al.. Antioxidant mechanisms of the improving effects of lentinan on learning and memory function in aging mice[J]. Chinese Journal of Gerontology, 2011, 31(4) | |
| Authors: | LU Ai-Mei YU Tian-Gui LI Wen-Jie et al. |
| Affiliation: | LU Ai-Mei,YU Tian-Gui,LI Wen-Jie,et al.Jinan Infectious Disease Hospital,Jinan 250021,Shandong,China |
| Abstract: | Objective To investigate the antioxidant mechanisms underlying the improving effects of lentinan(LNT) on learning and memory function in D-galactose(D-gal) inducing aging mice.Methods The aging mice were induced by subcutaneous injection of D-gal for 7 weeks.The learning and memory function of mice was tested by step down test.Not only the contents of malonaldehyde(MDA) but also the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in brain tissues were determined using different bi... |
| Keywords: | Lentinan(LNT) D-galactose(D-gal) Learning and memory Antioxidation |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |