| 正常人和精神分裂症患者脑灰质体积分析的性别效应 |
| |
| 引用本文： | 李丽,陶好娟,刘海洪,刘哲宁,薛志敏.正常人和精神分裂症患者脑灰质体积分析的性别效应[J].中国临床心理学杂志,2011,19(1). |
| |
| 作者姓名： | 李丽 陶好娟 刘海洪 刘哲宁 薛志敏 |
| |
| 作者单位： | 1. 中南大学湘雅二医院精神卫生研究所,湖南,长沙,410011
2. 中南大学湘雅医院心理中心,湖南,长沙,410008 |
| |
| 摘 要： | 目的:通过比较男性和女性正常人、男性和女性精神分裂症患者之间的脑灰质体积差异,探讨脑结构分析中的性别效应。方法:采集60例正常人(30例男性)和96例精神分裂症患者(48例男性)的高分辨率三维脑结构磁共振图像,运用基于体素的形态测量法(VBM)进行分析,获得每一个体的脑灰质体积图像。采用两样本t检验分别比较男性和女性正常人,男性和女性精神分裂症患者之间的脑灰质体积差异。结果:与女性正常人相比,男性正常人左侧的颞中回和额中回、右侧的边缘叶和颞中回的灰质体积较大(P<0.001),而左侧尾状核和右侧海马的灰质体积较小(P<0.001)。与女性精神分裂症患者相比,男性患者双侧的颞下回和海马、左侧的颞上回和颞中回的灰质体积较大(P<0.001),而未发现灰质体积较小的脑区。结论:性别效应是影响正常人或精神分裂症患者脑结构分析的重要因素。
|
| 关 键 词： | 精神分裂症 性别效应 灰质体积 基于体素的形态测量法 |
Sex Effects on the Gray Matter Volume in Normal Subjects or Schizophrenic Patients |
| |
| LI Li,TAO Hao-juan,LIU Hai-hong,LIU Zhe-ning,XUE Zhi-min.Sex Effects on the Gray Matter Volume in Normal Subjects or Schizophrenic Patients[J].Chinese Journal of Clinical Psychology,2011,19(1). |
| |
| Authors: | LI Li TAO Hao-juan LIU Hai-hong LIU Zhe-ning XUE Zhi-min |
| |
| Institution: | LI Li,TAO Hao-juan,LIU Hai-hong,LIU Zhe-ning,XUE Zhi-min Mental Health Institute,Second Xiangya Hospital,Central South University,Changsha 410011,China |
| |
| Abstract: | Objective:To explore the sex effects on brain structure.Methods:Normal subjects(n=60) and schizophrenic patients(n=96) were assigned into four groups:male(n=30) and female(n=30) normal subjects,male(n=48) and female(n=48) patients.Structural brain images were acquired for all subjects by magnetic resonance imaging machine,and the individual gray matter volume(GMV) images were obtained by the unified segmentation approach in voxel-based morphometry.The GMV difference between the male and female normal subjec... |
| |
| Keywords: | Schizophrenia Sex effect Gray matter volume Voxel-based morphometry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
