| 雄激素受体在不同分子亚型乳腺癌中的表达及其意义 |
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| 引用本文： | 于琦,牛昀,王淑玲,吕淑华,张静,刘子瑜. 雄激素受体在不同分子亚型乳腺癌中的表达及其意义[J]. 肿瘤防治研究, 2011, 38(2): 159-162. DOI: 10.3971/j.issn.1000-8578.2011.02.011 |
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| 作者姓名： | 于琦 牛昀 王淑玲 吕淑华 张静 刘子瑜 |
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| 作者单位： | 1.300060天津，天津医科大学附属肿瘤医院 乳腺癌防治教育部重点实验室 天津市肿瘤防治重点实验室；2.静海医院肿瘤科 |
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| 基金项目： | 天津市自然科学基金资助项目(09JCYBJC10100); 国家自然科学基金项目资助项目(30872519); 教育部长江学者和创新团队计划资助项目(TRT0743) |
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| 摘 要： | 目的探讨乳腺癌组织雄激素受体（androgen receptor，AR）的表达，分析其在各分子亚型中表达的特点及其意义。方法采用免疫组织化学方法检测AR在335例乳腺浸润性导管癌石蜡包埋组织中的表达，结合66月随访情况，分析AR在五个分子亚型中表达的特点。 结果乳腺癌组织中AR阳性率较高,达72.5%，尤其在ER阴性PR阴性乳腺癌病例，AR常常显示阳性（占53.2%）。较多 (61.0%) basal like型乳腺癌AR显示阴性，提示预后欠佳。在luminal A、luminal B、basal-like以及normal-like亚型中AR阳性组出现局部复发、远处转移或死亡比例较AR阴性组少(P=0.019，0.044，0.034和 0.032)，生存曲线也显示了AR阳性患者预后较好(P=0.006，0.013，0.036和0.010)。结论检测乳腺癌AR的表达水平有助于改进和细化乳腺癌的分子分型,为指导个体化治疗提供理论依据。
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| 关 键 词： | 雄激素受体 乳腺癌 分子分型 |
| 收稿时间： | 2010-06-07; |
Androgen Receptor Expression in Different Molecular Subgroups of Breast Cancer and Its Significance |
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| YU Qi,NIU Yun,WANG Shu-ling,LV Shu-hua,ZHANG Jing,LIU Zi-yu. Androgen Receptor Expression in Different Molecular Subgroups of Breast Cancer and Its Significance[J]. Cancer Research on Prevention and Treatment, 2011, 38(2): 159-162. DOI: 10.3971/j.issn.1000-8578.2011.02.011 |
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| Authors: | YU Qi NIU Yun WANG Shu-ling LV Shu-hua ZHANG Jing LIU Zi-yu |
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| Affiliation: | 1. Key Laboratory of Breast Cancer Prevention and Therapy,Tianjin Medical University,Ministry of Education and Key Laboratory of Cancer Prevention Therapy,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,China；2. Department of Oncology，Jinghai Hospital |
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| Abstract: | Objective To evaluate the expression of AR(androgen receptor,AR) in different molecular subgroups of breast cancer and its significance.Methods Three hundred and thirty-five cases of invasive ductal breast carcinoma were involved in this study.Immunohistochemical expression of AR on paraffin-embedded tumor tissues was analyzed,compared with patients' outcome during 66-months' follow-up observation,and its implications were evaluated in five molecular subgroups.Results A greater percentage(72.5%) of breast c... |
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| Keywords: | Androgen receptor Breast cancer Molecular subgroup |
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