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高血压左心室肥厚患者p22phox基因多态性与心房颤动的相关性研究
引用本文:盖晓波,黄明方,何家科,张志钢,侯建萍,陈哲明,林毅,杨湘越,郑卫星.高血压左心室肥厚患者p22phox基因多态性与心房颤动的相关性研究[J].解放军医学杂志,2010,35(1).
作者姓名:盖晓波  黄明方  何家科  张志钢  侯建萍  陈哲明  林毅  杨湘越  郑卫星
作者单位:1. 南京军区福州总医院心内科,福州,350025
2. 南京军区全军医学检验中心,福州,350025
基金项目:福建省科技厅科技计划重点项目基金(2007Y0029)
摘    要:目的探讨高血压左心室肥厚(LVH)患者p22phox基因C242T和-930A/G位点多态性与发生心房颤动(AF)的相关性。方法选择881例原发性高血压合并LVH患者,纳入其中128例合并心房颤动者作为AF组,在753例窦性心律患者中,根据年龄、性别、左室重量指数等临床资料与AF组进行1∶2配比,选择256例窦性心律者作为对照组。运用聚合酶链反应-限制性片段长度多态分析法检测p22phox基因C242T和-930A/G位点的多态性,比较两个位点的基因型及等位基因频率在两组间的分布差异。结果AF组p22phox基因C242T多态位点的TT和CT基因型以及T等位基因频率显著低于对照组(χ2=5.460,P=0.019;χ2=4.414,P=0.036)。多元logistic回归分析校正左房直径后,T等位基因携带者(TT+CT)发生房颤的风险约为CC型纯合子的0.5倍(OR=0.516,95%CI0.312~0.925,P=0.025)。p22phox基因-930A/G多态位点的基因型和等位基因频率在AF组与对照组间的分布无统计学差异。结论p22phox基因C242T位点的多态性与高血压LVH患者房颤的发生显著相关...

关 键 词:高血压  肥大  左心室  心房颤动  基因  p22phox  多态性  限制性片段长度  

Relationship between p22phox gene polymorphisms and atrial fibrillation in patients with hypertension and left ventricular hypertrophy
GAI Xiao-bo,HUANG Ming-fang,HE Jia-ke,ZHANG Zhi-gang,HOU Jian-ping,CHEN Zhe-ming,LIN Yi,YANG Xiang-yue,ZHENG Wei-xing.Relationship between p22phox gene polymorphisms and atrial fibrillation in patients with hypertension and left ventricular hypertrophy[J].Medical Journal of Chinese People's Liberation Army,2010,35(1).
Authors:GAI Xiao-bo  HUANG Ming-fang  HE Jia-ke  ZHANG Zhi-gang  HOU Jian-ping  CHEN Zhe-ming  LIN Yi  YANG Xiang-yue  ZHENG Wei-xing
Abstract:Objective To investigate the correlation between genetic variations of p22 phox gene(C242T and-930A/G)and the risk of atrial fibrillation(AF)in patients with hypertension and left ventricular hypertrophy(LVH).Methods A total of 881 consecutive patients with hypertension and LVH were admitted to Fuzhou General Hospital of Nanjing Command with or without a history of AF were included in the present study.One hundred and twenty-eight patients with AF were assigned into AF group.The remaining two hundred and fi...
Keywords:hypertension  hypertrophy  left ventricular  atrial fibrillation  genes  p22phox  polymorphism  restriction fragment length  
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