| 高血压左心室肥厚患者p22phox基因多态性与心房颤动的相关性研究 |
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| 引用本文： | 盖晓波,黄明方,何家科,张志钢,侯建萍,陈哲明,林毅,杨湘越,郑卫星.高血压左心室肥厚患者p22phox基因多态性与心房颤动的相关性研究[J].解放军医学杂志,2010,35(1). |
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| 作者姓名： | 盖晓波 黄明方 何家科 张志钢 侯建萍 陈哲明 林毅 杨湘越 郑卫星 |
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| 作者单位： | 1. 南京军区福州总医院心内科,福州,350025
2. 南京军区全军医学检验中心,福州,350025 |
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| 基金项目： | 福建省科技厅科技计划重点项目基金(2007Y0029) |
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| 摘 要： | 目的探讨高血压左心室肥厚(LVH)患者p22phox基因C242T和-930A/G位点多态性与发生心房颤动(AF)的相关性。方法选择881例原发性高血压合并LVH患者,纳入其中128例合并心房颤动者作为AF组,在753例窦性心律患者中,根据年龄、性别、左室重量指数等临床资料与AF组进行1∶2配比,选择256例窦性心律者作为对照组。运用聚合酶链反应-限制性片段长度多态分析法检测p22phox基因C242T和-930A/G位点的多态性,比较两个位点的基因型及等位基因频率在两组间的分布差异。结果AF组p22phox基因C242T多态位点的TT和CT基因型以及T等位基因频率显著低于对照组(χ2=5.460,P=0.019;χ2=4.414,P=0.036)。多元logistic回归分析校正左房直径后,T等位基因携带者(TT+CT)发生房颤的风险约为CC型纯合子的0.5倍(OR=0.516,95%CI0.312～0.925,P=0.025)。p22phox基因-930A/G多态位点的基因型和等位基因频率在AF组与对照组间的分布无统计学差异。结论p22phox基因C242T位点的多态性与高血压LVH患者房颤的发生显著相关...
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| 关 键 词： | 高血压 肥大 左心室 心房颤动 基因 p22phox 多态性 限制性片段长度 |
Relationship between p22phox gene polymorphisms and atrial fibrillation in patients with hypertension and left ventricular hypertrophy |
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| GAI Xiao-bo,HUANG Ming-fang,HE Jia-ke,ZHANG Zhi-gang,HOU Jian-ping,CHEN Zhe-ming,LIN Yi,YANG Xiang-yue,ZHENG Wei-xing.Relationship between p22phox gene polymorphisms and atrial fibrillation in patients with hypertension and left ventricular hypertrophy[J].Medical Journal of Chinese People's Liberation Army,2010,35(1). |
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| Authors: | GAI Xiao-bo HUANG Ming-fang HE Jia-ke ZHANG Zhi-gang HOU Jian-ping CHEN Zhe-ming LIN Yi YANG Xiang-yue ZHENG Wei-xing |
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| Abstract: | Objective To investigate the correlation between genetic variations of p22 phox gene(C242T and-930A/G)and the risk of atrial fibrillation(AF)in patients with hypertension and left ventricular hypertrophy(LVH).Methods A total of 881 consecutive patients with hypertension and LVH were admitted to Fuzhou General Hospital of Nanjing Command with or without a history of AF were included in the present study.One hundred and twenty-eight patients with AF were assigned into AF group.The remaining two hundred and fi... |
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| Keywords: | hypertension hypertrophy left ventricular atrial fibrillation genes p22phox polymorphism restriction fragment length |
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