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| Fas及FasL在大鼠肝癌促癌过程中的表达及作用 | |
| 引用本文： | 龙冬梅,冷言冰,王登高,刘友生,高宁,翟庆燕. Fas及FasL在大鼠肝癌促癌过程中的表达及作用[J]. 西南国防医药, 2003, 13(2): 126-129 |
| 作者姓名： | 龙冬梅 冷言冰 王登高 刘友生 高宁 翟庆燕 |
| 作者单位： | 1. 第三军医大学预防医学系环境卫生学教研室,重庆,400038 2. 第三军医大学成都军医学院 3. 第三军医大学西南医院病理研究所 |
| 基金项目： | 国家自然科学基金资助NO:39770 6 37 |
| 摘 要： | 目的：研究Fas及FasL在实验性大鼠肝促癌过程中的表达及作用。方法：复制大鼠肝癌启动／促进模型，用免疫组化方法大鼠肝促癌过程中Fas及FasL蛋白表达情况。结果：正常组大鼠肝细胞Fas呈弱阳性表达，经启动处事后的各组（高、中、低剂量组和启动组)Fas表达增强，高、中剂量组在给予促癌物PB后1周—15周，Fas呈强阳性表达，在给予PB15周后，Fas表达明显呈下降趋势，其余各组Fas表达未见明显改变。正常组和促癌组未见FasL蛋白表达，其余各组可见Fas表达。高剂量组和中剂量组在加促癌物PB后15周，FasL蛋白表达明显增多。结论：Fas表达下调同时FasL表达上调可能参与促癌过程。 |
| 关 键 词： | 肝癌 促癌过程 Fas FasL 肝细胞 促癌物 大鼠 |
| 修稿时间： | 2002-03-26 |
The expression and effect of Fas and FasL in rat liver tumor promotion by phenobarbital |
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| LONG Dong-mei ,LENG Yan-bing ,WANG Deng-gao ,LIU You-sheng ,GAO Ning Division of Environment Hygiene. The expression and effect of Fas and FasL in rat liver tumor promotion by phenobarbital[J]. Medical Journal of National Defending forces in Southwest China, 2003, 13(2): 126-129 | |
| Authors: | LONG Dong-mei LENG Yan-bing WANG Deng-gao LIU You-sheng GAO Ning Division of Environment Hygiene |
| Affiliation: | LONG Dong-mei 1,LENG Yan-bing 2,WANG Deng-gao 2,LIU You-sheng 3,GAO Ning 1 1 Division of Environment Hygiene,Department of Preventive Medicine,Third Military Medical University,Chongqing 400038 2 Chengdu Military Medical College,Third Military Medical University 3 Institute of Pathology,Westsouth Hospital of Third Military Medical University |
| Abstract: | Objective:To explore the expression and effect of Fas and FasL in rat liver tumor promotion by phenobarbital(PB) Methods:The rat liver initiating-promoting model was established by DEN treatment(initiating)followed by a selection phase(2-AFF treatment and partial hepatectomy)and then by PB-promoting Immunohistochemistry was used to investigate the expression of Fas and FasL Results:It was shown that Fas exfression level in all initiated groups(high-dose,middle-dose,low-dose and initiating group)was higher than that in normal control group;however,FasL was not observed in normal group or promoting group but expressed in other groups After 15 weeks of administration of PB,Fas protein in high-dose and middle-dose group declined significantly while FasL protein increased remarkably Conclusion:The results suggested that down-regulation of Fas and up-regulation of FasL might participate in the tumor promotion of rat liver by PB,while its mechanism still remain unclarified |
| Keywords: | Fas FasL tumor promotion |
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