House dust mite allergy

To study efficacy of a purified and biologically standardized house dust mite extract 66 allergic children were investigated. 26 patients on immunotherapy and 21 controls with symptomatic treatment only finished the study. A significant reduction of the skin reactivity associated with an increase of allergen specific IgG-antibodies was observed. However, no significant differences were found correlating the results of inhalative provocation tests, specific IgE antibodies and symptom scores. The immunotherapy with house dust mite extracts needs further evaluation.