雌激素受体阳性乳腺癌预后的相关因素分析

目的 探讨影响雌激素受体（ER）阳性乳腺癌患者预后的因素。 方法 收集2006年1月至2009年11月诊治的229例ER阳性乳腺癌患者的临床和随访资料，分析其临床病理参数中与预后相关的因素。将发病年龄、月经状况、肿瘤大小、淋巴结转移率（LNR）、PR表达、Her-2表达、组织学分级、新辅助化疗及放疗等因素进行Kaplan-Meier单因素和Cox回归多因素生存分析。 结果 获随访的223例患者的复发率为15.70％。Cox模型多因素生存分析显示：肿瘤大小、LNR、Her-2表达及PR表达均为影响ER阳性患者接受内分泌治疗后无复发生存的独立因素（P＜0.05）。 结论 肿瘤越大、Her-2过表达、PR阴性及LNR较高是ER阳性乳腺癌复发转移的独立危险因素。

Analysis of prognosis-related factors for breast cancer with positive estrogen receptors

Objective To investigate the related factors for prognosis of estrogen receptor（ER）-positive breast cancer. Methods The clinical and pathological data of 229 patients with ER-positive breast cancer from Jan 2006 to Nov 2009 were collected. The onset of age， menstrual status， tumor size， tumor grade， lymph node ratio（LNR）， expression patterns of PR and Her-2， neoadjuvant chemotherapy and radiotherapy were analyzed by Kaplan-Meier survival plots and multivariable Cox hazard regression analysis to identify prognostic factors for survival. Results In this retrospective analysis，15.70％ of 223 patients who had completed the follow-up suffered from local recurrence or metastasis. The Cox regression revealed that the tumor size， LNR， expression patterns of PR and Her-2 affected the recurrence-free survival after the endocrine therapy of breast cancer. Conclusion Large size of tumor， high LNR， over-expression of Her-2 and loss of PR are risk factors for recurrence／metastasis of ER-positive breast cancer.