δ-Aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines |
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| Authors: | Adriana De Siervi Elba S Vazquez Carolina Rezaval María V Rossetti Alcira M del Batlle |
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| Affiliation: | (1) Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), Argentine National Research Council (CONICET), Department of Biological Chemistry, FCEN, University of Buenos Aires, Argentina |
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| Abstract: | Background Acute Intermittent Porphyria is a genetic disorder of heme metabolism, characterized by increased levels of porphyrin precursors, δ-aminolevulinic acid (ALA) and porphobilinogen (PBG). ALA has been reported to generate reactive oxygen species and to cause oxidative damage to proteins, subcellular structures and DNA. It is known that oxidative stress can induce apoptosis. The aim of this work was to study the cytotoxic effect of ALA on two hepatocarcinoma cell lines. |
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