Lipid abnormalities in stable liver transplant recipients – effects of cyclosporin, tacrolimus, and steroids |
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Authors: | C Fernández-Miranda C Guijarro A del Palacio A de la Calle C Loinaz I Gonzalez-Pinto E Moreno T Gómez-Izquierdo S Larumbe |
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Institution: | (1) Department of Internal Medicine, Hospital Universitario 12 de Octubre, Ctra. Andalucía Km. 5400, E-28 041 Madrid, Spain Fax + 34 1 390 8358, ES;(2) Department of Surgery Hospital Universitario 12 de Octubre, Ctra. Andalucía Km. 5400, E-28 041 Madrid, Spain, ES;(3) Department of Biochemistry Hospital Universitario 12 de Octubre, Ctra. Andalucía Km. 5400, E-28 041 Madrid, Spain, ES |
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Abstract: | Dyslipidemia is common after liver transplantation, but the underlying
mechanisms are largely unknown. We studied the lipid profile of 27 liver transplant recipients randomized to receive either
cyclosporin (CyA, n = 14) or tacrolimus (n = 13) and compared them with 20 healthy, matched controls. Before transplantation, patients presented low total and low-density
lipoprotein (LDL) cholesterol (as compared to controls) that increased shortly, i. e., 3 months, after transplantation. Eighteen
months post-transplantation, total and LDL cholesterol levels decreased to pretransplant values but tended to remain higher
in CyA-treated patients. However, at that time, prednisone treatment was more prevalent among CyA-treated than tacrolimus-treated
patients and fully accounted for the difference in cholesterol levels. Indeed, regardless of therapy, patients not receiving
prednisone exhibited lower cholesterol levels than prednisone-treated patients and controls. We conclude that prednisone therapy,
rather than CyA or tacrolimus immunosuppression, seems to be the major determinant of increased cholesterol levels.
Received: 19 June 1997 Received after revision: 24 October 1997 Accepted: 10 November 1997 |
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Keywords: | Lipoproteins liver transplantation immunosuppression Liver transplantation lipoproteins immunosuppression Immunosuppression liver transplantation lipoproteins |
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