| 联合应用bFGF和IGF-1对大鼠正畸牙移动过程中牙周组织改建的影响 |
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| 引用本文： | 吴立鹏,柳田甜.联合应用bFGF和IGF-1对大鼠正畸牙移动过程中牙周组织改建的影响[J].黑龙江医药科学,2009,32(4):16-17. |
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| 作者姓名： | 吴立鹏 柳田甜 |
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| 作者单位： | 佳木斯大学附属口腔医院,黑龙江,佳木斯,154002 |
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| 摘 要： | 目的：通过局部单独及联合应用bFGF和IGF-1．探讨两种生长因子对大鼠正畸牙移动过程中牙周组织改建的影响。方法：将大鼠随机分成二组，对照组岫FGF＋IGF-1组．每组20只。于大鼠上颌左侧第一磨牙与上切牙之间安装一闭隙镍钛拉簧，力值50g。二组分别隔日在正畸牙颊侧牙龈黏膜下注射生理盐水0．1mL；bFGF＋IGF—1，200ng／m＋1mg／mL备0．1mL。并在正畸加力后的第1、3、7、14、21d每组各处死四只。制备牙体-牙周组织标本，HE染色和免疫组化染色，统计学分析。结果．bFGF＋IGF-1组与对照组比较（压力侧和张力侧）在7d、14d、21d有差异（P〈0．05）。结论出FGF和IGF-1的联合应用对大鼠正畸牙移动中牙周组织的改建有促进作用。
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| 关 键 词： | bFGF IGF1- 正畸力 牙周组织 |
Influence of combinative application of bFGF and IGF-1 upon periodontium remodeling in orthodontic tooth movement in rats |
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| WU Li-peng,LIU Tian-tian.Influence of combinative application of bFGF and IGF-1 upon periodontium remodeling in orthodontic tooth movement in rats[J].Heilongjiang Medicine and Pharmacy,2009,32(4):16-17. |
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| Authors: | WU Li-peng LIU Tian-tian |
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| Institution: | The College of Stomatology of Jiamusi University;Jiamusi 154002;China |
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| Abstract: | Objective: To investigate the effect of two kinds of growth factors on orthodontic tooth movement in rats by the combinative application of bFGF and IGF-1.Methods:Rats were randomly divided into two groups,control group and bFGF+IGF-1group,with 20 in each group.Orthodontic appliances were placed between the maxillary first molar in the left and maxillary central incisors of rats,with 50-gram force.We injected 0.1mL of Physiological saline,0.1mL of bFGF+IGF-1 200ng/m +1mg/mL each to the two groups every othe... |
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| Keywords: | bFGF IGF-1 |
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