UAP患者血清IL-6、TNF、CRP测定的临床应用

目的：观察不稳定性心绞痛（UAP）患者白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、C-反应蛋白（CRP）含量改变。方法：用放射免疫分析对28例UAP患者血清IL-6、TNF含量检测，生化仪测CRP，并用稳定性心绞痛（SAP）组和正常对照组作比较。结果：uAP组患者血清TNF、IL-6,CRP含量明显高于非心绞痛组（P〈0.01）和正常对照组（P〈0．01）。结论：在UAP患者测血清TNF、IL-6、CRP有较好的诊断价值和鉴别诊断价值，对UAP的治疗、预后亦有一定的参考价值。

Clinical Significance of Measurement of Serum Levels of Interleukin-6,Tumor Necrosis Factor and C-reactive Protein in Patients with Unstable Angina Pectoris

Objective To observe the changes of the serum contents of tumor necrosis factor(TNF),interleukin-6(IL-6) and C-reactive protein(CRP) in patients with unstable angina pectoris(UAP).Methods Serum tumor necrosis factor(TNF) and interleukin-6(with RIA) C-reactive protein(CRP)(with biochemical methods) were measured in 28 patients with UAP,29 patients with stable angina pectoris(SAP) and 31 controls.Results The unstable angina pectoris(UAP) group.The serum contents of tumor necrosis factor(TNF),Interleukin-6(IL-6) and C-reactive protein(CRP) in the UAP patients were significantly higher than those in the SAP patients and controls(P<0.01).Conclusion Determination of serum tumor necrosis factor(TNF),interleukin-6(IL-6) and C-reactive protein (CRP) contents in patients with UAP is of diagnostic and prognostic value.