| 高山尖杉酯碱抑制鸡胚绒毛尿囊膜血管生成 |
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| 引用本文： | 刘剑平,谢传美,贾科,杨泽松. 高山尖杉酯碱抑制鸡胚绒毛尿囊膜血管生成[J]. 川北医学院学报, 2003, 18(2): 9-11 |
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| 作者姓名： | 刘剑平 谢传美 贾科 杨泽松 |
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| 作者单位： | 川北医学院附属医院风湿血液科,四川,南充,637000 |
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| 摘 要： | 目的 了解高山尖杉酯碱 (H)对血管生成的影响 ,为进一步研究打基础。方法 于发育第 8天的鸡胚绒毛尿囊膜(CAM)上植入明胶海绵载体 ,其中加入不同剂量的H ,计数长入载体的血管和载体内的微管密度 (MVD)。结果 在CAM上 ,长入载体边缘的血管数和MVD在 10 0ng以上组与对照组间的差别有统计学意义 (p <0 .0 1)。结论 在CAM中 ,10 μg/kg的低剂量能抑制CAM的血管生成 ,显示了H有较强的抗血管生成活性
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| 关 键 词： | 高山尖杉酯碱 血管生成 鸡胚绒毛尿囊膜 |
| 文章编号： | 1005-3697(2003)02-0009-02 |
Inhibition of angiogenesis on CAM by homoharringtonine |
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| LIU Jian_ping,XIE Chuan_mei,JIA Ke,YANG Zhe_song. Inhibition of angiogenesis on CAM by homoharringtonine[J]. Journal of North Sichuan Medical College, 2003, 18(2): 9-11 |
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| Authors: | LIU Jian_ping XIE Chuan_mei JIA Ke YANG Zhe_song |
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| Abstract: | Objectives The study was to reveal the inhibition of angiogenesis on CAM by homoharringtonine (H). Method Gelatin sponges were implanted on top of CAM,when chick embryos developed on day 8, vessels which towards gelatin and microvascular density (MVD) in gelatin were counted on day 12. Results On CAM model, numbers of vessels at the sponge-CAM boundary and MVD were significantly different (p<0.01).Conclusion The study has shown the antiangiogenesis on CAM model by H at low dose. |
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| Keywords: | homoharringtonine angiogenesis chick embryo chorioallantoic membrane |
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