C-erbB-2 oncogene amplification in breast cancer in correlation to steroid and epidermal growth factor receptor] |
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| Authors: | M Manavi K F Czerwenka R Zeillinger P Speiser F Kury U Steinhart M Peschke E Kubista E Reinold |
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| Affiliation: | I. Universit?ts-Frauenklinik Wien. |
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| Abstract: | The amplification grade of oncogene c-erbB-2 was examined by the polymerase-chain-reaction-method in DNA's of 56 primary mammary carcinomas. 26 (46.4%) of these showed the amplified oncogene c-erbB-2. In the strongly amplified cases, the expression of the c-erbB-2 oncoprotein was verifiable immunohistochemically. Between the progesterone receptor status (PR) and the amplified c-erbB-2 oncogene there was a statistically proven dependency. No correlation was observed between the amplified c-erbB-2 oncogene and the epidermal growth-factor receptor (EGFR). |
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