| 人尿中氢可酮及其代谢物的检测研究 |
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| 引用本文： | 吴筠.人尿中氢可酮及其代谢物的检测研究[J].药学学报,1997,32(4):305-309. |
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| 作者姓名： | 吴筠 |
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| 作者单位： | 国家体委运动医学研究所兴奋剂检测中心 |
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| 摘 要： | 用气相色谱 质谱联用仪(GC/MSD)检测人尿中氢可酮及其代谢物双氢吗啡。尿样经酸解、乙醚/异丙醇提取后,用甲氧胺吡啶液将羰基保护生成肟,再用MSTFA-MBTFA及MSTFA-TMSI衍生化后,经GC/MS分析,形成各自的特征图谱。方法灵敏、准确,可快速鉴别氢可酮、可待因、双氢可待因等结构相似药物。
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| 关 键 词： | 氢可酮 可待因 双氢可待因 GC/MS |
| 收稿时间： | 1996-06-10 |
STUDIES ON THE ANALYSIS OF HYDROCODONE AND ITS METABOLITE IN HUMAN URINE BY GC/MS |
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| Y Wu.STUDIES ON THE ANALYSIS OF HYDROCODONE AND ITS METABOLITE IN HUMAN URINE BY GC/MS[J].Acta Pharmaceutica Sinica,1997,32(4):305-309. |
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| Authors: | Y Wu |
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| Institution: | National Research Institute of Sports Medicine, Beijing 100029. |
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| Abstract: | The method for the analysis of hydrocodone and its metabolite in urine by GC/MSD is reported. The urine was hydrolysed with HCl and extracted with diethyl ether/isopropanol. The gas chromatography/mass spectrometric properties of trimethylsilyl ether of hydrocodone, first reacted with methoxyamine to protect the carbonyl group, were studied. This method is sensitive and rapid for the determination of hydrocodone, codeine and dihydrocodeine. |
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| Keywords: | Hydrocodone Codeine Dihydrocodeine GC/MSD |
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