失眠伴便秘型肠易激综合征患者睡眠特征及胃动素、生长抑素的临床观察

目的观察失眠伴便秘型肠易激综合征患者的睡眠特征及胃动素、生长抑素水平，为临床治疗提供依据。方法对同期连续就诊的失眠伴便秘型肠易激综合征患者及失眠不伴便秘型肠易激综合症患者（各12例）进行多导睡眠检测，同时设立健康志愿者（8人）作为对照。采用多导睡眠仪对上述试验者进行整晚监测，第二天晨起用放免法测定血浆胃动素、生长抑素水平。结果失眠伴便秘和不伴便秘组的睡眠时间、深睡眠时间、深睡眠比例、快眼动（REM）时间以及睡眠效率均较正常对照组显著减少；在总记录时间、REM次数、REM比例三组无显著性差异。失眠伴便秘患者胃动素较正常对照组明显升高（271．89pg／mL±51．25pg／mLvs240．85pg／mL±41．41pg／mL，P〈0．05），升高幅度较失眠不伴便秘患者（315．49Pg／mL±19．32pg／mL）低；其生长抑素水平亦较对照组明显升高（505．49pg/mL±30．49pg／mLvs438．32pg／mL±23．67pg／mL，P〈0．05）。结论失眠与便秘型肠易激综合征关系密切。失眠伴有便秘型肠易激综合征患者胃动素、生长抑素水平增高。

The clinical observation on sleep character, and levels of motilin and somatostatin in patients with insomnia and constipation-predominant irritable bowel syndrome

Objective To observe the character of the sleep and to detective the levels of motilin and somatostatin in patients with insomnia and constipation-predominant irritable bowel syndrome （C-IBS）. Methods Data of 12 patients with insomnia and C-IBS, 12 patients only with insomnia and 8 normal volunteers were collected. Patients slept one night in the sleep laboratory and monitored by polysomnography to determine sleep patterns. Motilin and somatostain were detected by radioimmunoassay in the next morning. Results Total sleep time, total SWS （slow wave sleep） , percentage SWS, total REM time, sleep efficiency in patients with insomnia and/or without constipation were significantly lower than those in the normal volunteers. There was no significant difference in total sleep time, total REM time and percentage REM among three groups. The levels of the motilin in the patients with insomnia and constipation were signif- icantly higher than that in the normal volunteers （271.89 pg/mL ±51.25 pg/mL vs 240.85 pg/mL± 41. 41 pg/mL, P 〈 0. 05）, but the levels of the motilin were lower than that in the patients with insomnia without constipation （315.49 pg/mL ±19.32 pg/mL）. The levels of the somatostain in the patients with insomnia and constipation were significantly higher than that in the normal volunteers （505.49 pg/mL±30.49 pg/mL vs 438.32 pg/mL±23.67 pg/mL, P 〈 0.05）. Conclusion Insomnia is related with C-IBS. Patients with insomnia and constipation had significantly higher levels in motilin and somatostain than the normal volunteers.