Bi‐exponential 23Na T2* component analysis in the human brain |
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| Authors: | Frank Riemer Bhavana S Solanky Claudia AM Wheeler‐Kingshott Xavier Golay |
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| Institution: | 1. Queen Square MS Centre, NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK;2. Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK |
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| Abstract: | The purpose of this study was to measure the sodium transverse relaxation time T2* in the healthy human brain. Five healthy subjects were scanned with 18 echo times (TEs) as short as 0.17 ms. T2* values were fitted on a voxel‐by‐voxel basis using a bi‐exponential model. Data were also analysed using a continuous distribution fit with a region of interest‐based inverse Laplace transform. Average T2* values were 3.4 ± 0.2 ms and 23.5 ± 1.8 ms in white matter (WM) for the short and long components, respectively, and 3.9 ± 0.5 ms and 26.3 ± 2.6 ms in grey matter (GM) for the short and long components, respectively, using the bi‐exponential model. Continuous distribution fits yielded results of 3.1 ± 0.3 ms and 18.8 ± 3.2 ms in WM for the short and long components, respectively, and 2.9 ± 0.4 ms and 17.2 ± 2 ms in GM for the short and long components, respectively. 23Na T2* values of the brain for the short and long components for various anatomical locations using ultra‐short TEs are presented for the first time. |
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| Keywords: | 23Na neuro non‐Cartesian relaxometry sodium UTE |
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