bFGF在血管瘤和血管畸形中的表达

目的　了解碱性纤维母细胞生长因子 (b FGF)与血管瘤及血管畸形的关系。方法　采用免疫组织化学 SP法 ,对 72例血管瘤和 2 0例血管畸形组织切片的 b FGF表达进行测定。结果　b FGF在血管瘤组织中高表达 ,而在血管畸形组织中低表达 (P<0 .0 1)。在血管瘤增殖期、退化早期和退化完成期三者之间 ,b FGF的表达存在着差异。血管内皮细胞增生程度越高 ,b FGF的表达越高 (P<0 .0 5 )。结论　b FGF与血管瘤的增殖和退化有关 ,与血管畸形无明显关系。

Studies on the Relationship between Basic Fibroblast Growrh Factor and Hemangioma and Vascular Malformation

Objective To understand the relationship between basic fibroblast growth factor(bFGF) and hemangioma(H)and vascular malformation(VM).Methods The expression of bFGF of the tissue sections of 72 cases with H and 20 VM were examined with SP immunohistochemistry.Results The expression of bFGF was significantly higher in the tissue of H and lower in the tissue of VM(P<0.01).There were significantly different expressions of bFGF in H among proliferative,early degenerative and completed degenerative phase:the higher the degree of proliferation of vascular endothelium ,the higher expression of bFGF(P<0.05).Conclusion bFGF was definitely related to the proliferation and degeneration of H,but was not remarkably related to VM.