| 自噬与肿瘤关系的研究进展 |
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| 引用本文： | 庄睿丹,李军建,陈伟,梁廷波. 自噬与肿瘤关系的研究进展[J]. 国际外科学杂志, 2009, 36(9). DOI: 10.3760/cma.j.issn.1673-4203.2009.09.021 |
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| 作者姓名： | 庄睿丹 李军建 陈伟 梁廷波 |
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| 作者单位： | 浙江大学医学院附属第一医院肝胆胰外科,杭州,310003;浙江大学医学院附属第一医院肝胆胰外科,杭州,310003;浙江大学医学院附属第一医院肝胆胰外科,杭州,310003;浙江大学医学院附属第一医院肝胆胰外科,杭州,310003 |
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| 摘 要： | 自噬是细胞内以双层膜结构包裹并与溶酶体融合降解长寿命蛋白及细胞器的过程,是胞内物质更新和营养再利用的途径.自噬能力的改变与肿瘤的发生、发展密切相关,自噬及其调节的相关基因与癌基因、抑癌基因有许多交叉,而自噬调节性死亡又为肿瘤的治疗打开了一条新的思路.
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| 关 键 词： | 自噬 肿瘤 信号通路 |
Advance in relationship between autophay and tumor |
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| ZHUANG Rui-Dan,LI Jun-Jian,CHEN Wei,LIANG Ting-Bo. Advance in relationship between autophay and tumor[J]. International Journal of Surgery, 2009, 36(9). DOI: 10.3760/cma.j.issn.1673-4203.2009.09.021 |
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| Authors: | ZHUANG Rui-Dan LI Jun-Jian CHEN Wei LIANG Ting-Bo |
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| Abstract: | Autophagy is known as cellular degradation of long-lived proteins and organelles, by a double-membranound structure fusing with the lysosome, for recycling intraceUular constituents and reusing nutri-tion. Defective autophagy is closely correlated with tumorigenesis and tumor progress. There are crosstalks between autophay associated/regulative genes and oncogene/anti-oncogene. More over, regulative autophagic cell death may lead to an novol way for cancer therapy. |
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| Keywords: | autophagy tumor signal pathway |
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