| 卡维地洛人体药代动力学研究 |
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| 引用本文： | 于常声,刘晓燕,袁桂艳,王本杰,郭瑞臣.卡维地洛人体药代动力学研究[J].齐鲁药事,2009,28(2):108-110. |
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| 作者姓名： | 于常声 刘晓燕 袁桂艳 王本杰 郭瑞臣 |
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| 作者单位： | 1. 山东省电力中心医院药剂科,山东,济南,250001;山东大学医学院,山东,济南,2500123
2. 山东大学齐鲁医院临床药理研究所,山东,济南,250012 |
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| 摘 要： | 目的进行卡维地洛片人体药代动力学研究。方法采用高效液相色谱法(荧光)测定卡维地洛经时血浓度。以DAS2.0实用药代动力学计算程序计算卡维地洛药代动力学参数。结果卡维地洛片主要药动学参数t12为3.417±1.739h,Tmax为1.188±0.343h,Cmax为44.645±17.446ng·mL-1,AUC0～24为156.113±69.710ng·mL-1.h,AUC0～∞为160.980±69.730ng·mL-1.h。结论该方法准确、灵敏,可用于卡维地洛片人体药代动力学研究。
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| 关 键 词： | 卡维地洛 药代动力学 高效液相色谱法 荧光 |
Study on pharmacokinetic of carvedilol |
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| YU Chang-sheng,LIU Xiao-yan,YUAN Gui-yan,WANG Ben-jie,GUO Rui-chen.Study on pharmacokinetic of carvedilol[J].qilu pharmaceutical affairs,2009,28(2):108-110. |
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| Authors: | YU Chang-sheng LIU Xiao-yan YUAN Gui-yan WANG Ben-jie GUO Rui-chen |
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| Institution: | 1.Shandong Province Electric Hospital;Ji'nan 250001;2.School of Medicne;Shandong University;Ji'nan 250012;3.Institute of Clinical Pharmacology;Qilu Hospital of Shandong University;Ji'nan 250012 |
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| Abstract: | OBJECTIVE To study the pharmacokinetic properties of Carvedilol Tablet in 20 healthy male subjects. METHODS Plasma concentrations of carvedilol after a single dose of 20mg were determined by reversed-- phase HPLC method with fluorescence detection, and the pharmacokinetic parameters were calculated by DAS2.0. RESULTS The main pharmacokinetic parameters of carvedilol,as t1/2 ,Tmax AUC0-24 and AUC0-∞ were 3. 417±1. 739h,1. 188±0. 343h,44. 645±17. 446ng·mL^-1 ,156. 113±69. 710ng·mL^-1·h and 160. 980±69. 730ng ·mL^-1· h respectively. CONCLUSION The method was sensitive and accurate,and was successfully applied to the pharmacokinetic study of carvedilol in human. |
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| Keywords: | Carvedilol pharmacokinetics HPLC fluorescence |
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