BAG-1在非小细胞肺癌中的表达及意义 |
| |
引用本文: | 哈敏文,李建鹏,巩克亭,李雪,邢永达,朱志图. BAG-1在非小细胞肺癌中的表达及意义[J]. 广东医学, 2010, 31(12) |
| |
作者姓名: | 哈敏文 李建鹏 巩克亭 李雪 邢永达 朱志图 |
| |
作者单位: | 1. 辽宁医学院附属第一医院肿瘤科,辽宁锦州,121001 2. 山东省新泰市人民医院,271200 3. 山东省新泰市计划生育服务站,271200 |
| |
基金项目: | 辽宁省科技厅攻关项目 |
| |
摘 要: | 目的:探讨BAG-1在非小细胞肺癌(non-small cell lung cancer, NSCLC)中差异的表达,了解其与NSCLC临床病理特征之间的关系。方法:应用免疫组化与RT-PCR方法,检测80例NSCLC 术后癌组织及其癌旁组织标本中BAG-1蛋白与mRNA的表达。结果:BAG-1在NSCLC中阳性表达率71.25%,与癌旁组织相比存在显著差异(P<0.05),并且其表达与肿瘤细胞分化程度有关。结论:BAG-1作为抗凋亡基因在NSCLC的发生发展过程中起了重要作用,可能成为预测NSCLC恶性程度的新的生物学及个体化治疗的敏感指标。
|
关 键 词: | 非小细胞肺癌 免疫组化 个体化治疗 |
Roles of BAG-1 in non-small cell lung cancer |
| |
Abstract: | Objective: This study was designed to investigate the expreesion of BAG-1 in non-small cell lung cancer(NSCLC)and its clinical significance.Method:The expreesion of BAG-1 in 80 NSCLC tissues and paired tumor - adjacent tissues were examined by immunohistochemical staining and RT-PCR.Results: The positive rates of BAG-1 in NSCLC tissues were significantly higher than that in tumor - adjacent tissues ,and the positive rates was also related to the differentiation degree . Conclusion : BAG-1 is the one of anti-apoptosis genes,and its, overexpression plays an important role in development and progression of NSCLC. It may become a new indicator of malignant degree and individualized treatment . |
| |
Keywords: | BAG-1 |
本文献已被 CNKI 万方数据 等数据库收录! |
| 点击此处可从《广东医学》浏览原始摘要信息 |
|
点击此处可从《广东医学》下载全文 |
|