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Phase II double-blind randomized study of lonidamine and radiotherapy in epidermoid carcinoma of the lung |
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| Authors: | Giuseppe Privitera Giovanni Battista Ciottoli Carmelo Patan Tullio Palmucci Gaetano Tafuri Francesco Marletta Bruno De Luca Francesco Magnani Mauro De Gregorio Stefano Greco |
| Affiliation: | 1Istituto Radiologia Medica, Università, Catania, Italy 2Istituto di Ricerca F. Angelini, Rome, Italy |
| Abstract: | Patients with non metastatic squamous cell lung cancer were treated with radiotherapy (RT) plus lonidamine (LND) or placebo (PLAC), according to a randomized double-blind study design. Treatment with lonidamine 150 mg t.i.d (27 patients) or placebo (23 patients) started 3 days before RT,lasted up to 7 months. Partial responses were observed in 14 and 6 patients respectively in the LND+RT and PLAC+RT groups. Statistical analysis of the survival curves showed no significant difference between the LND+RT (median 311 days) and PLAC+RT (median 193 days) groups. Stage III patients survived significantly longer (p<0.05) when treated with LND+RT (median 318 days) than with PLAC+RT (median 163 days). No synergistic toxic effects between radiation and LND were noted. To confirm these data a new and larger multicentric study is now in progress. |
| Keywords: | Lonidamine Radiotherapy Epidermoid lung cancer |
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