| 抗Tac单克隆抗体对ConA诱导小鼠实验性肝损伤的影响 |
| |
| 引用本文： | 李小刚,王天才,唐望先,李绍白,张文英,杜荔菁.抗Tac单克隆抗体对ConA诱导小鼠实验性肝损伤的影响[J].现代免疫学,1996,16(4):203-205. |
| |
| 作者姓名： | 李小刚 王天才 唐望先 李绍白 张文英 杜荔菁 |
| |
| 作者单位： | 武汉同济医科大学同济医院肝病研究所，湖北省荆沙市一医院 |
| |
| 摘 要： | 本研究采用ＣｏｎＡ诱导，建成小鼠肝损伤模型，并检测其血浆肿瘤坏死因子－α（ＴＮＦ－α）含量的变化，发现模型组鼠血浆ＴＮＦ－α含量为０．１９±０．０６ｎｇ／ｍｌ，而正常对照组未检出ＴＮＦ－α，二者比较有极显著差异（Ｐ＜０．００１）。预先注射抗Ｔａｃ单克隆抗体可减少ＣｏｎＡ注射后小鼠ＴＮＦ－α的产生，与模型组比较（分别为０．０３±０．０２和０．１９±０．０６），二者有极显著差异（Ｐ＜０．００１），而且注射抗Ｔａｃ单抗组无肝损伤发生。上述结果表明，ＣｏｎＡ诱导的肝损伤与ＴＮＦ－α等的介导有关，抗Ｔａｃ单克隆抗体对ＣｏｎＡ诱导的肝损伤有保护作用。
|
| 关 键 词： | 白细胞介素2受体，单克隆抗体，刀豆蛋白A，肝损伤 |
Effect of Monoclonal anti-Mouse Tao Antibody on the ConA InducedLiver Damage in Mice |
| |
| Li Xiaogang,Wang Tiancai,Tang Wangxian,Li Shaobai,Zhang Wenying,Du Lijing.Effect of Monoclonal anti-Mouse Tao Antibody on the ConA InducedLiver Damage in Mice[J].Current Immunology,1996,16(4):203-205. |
| |
| Authors: | Li Xiaogang Wang Tiancai Tang Wangxian Li Shaobai Zhang Wenying Du Lijing |
| |
| Abstract: | The present study was designed to establish experimental liver injary model byConA in mice and to detect the changes of plasma TNF-α in this model.The resultsshowed that plasma TNF-α was significantly higher in experimental mice than incontrol.The production of TNF-α was significantly reduced in mice pretreated withmonoclonal anti-mouse Tao antibody.It is most likely that liver injury induced byConA are associated with the induction of TNF-α.Monoclonal anti-mouse Tac antibadg have protection on the ConA induced liver injury. |
| |
| Keywords: | interleukin-2 receptor(IL-2R)monoclonal antibody concanavalin A live injury |
| 本文献已被 CNKI 等数据库收录！ |
