老年男性ApoA／ApoB与代谢综合征及其各组分相关性研究

目的探讨老年男性中载脂蛋白A／载脂蛋白B（ApoA／ApoB）与代谢综合征（metabolic syndrome，MS）及其相关组分的关系。方法采用横断面调查方法，选取2006年6月至2006年12月在我科进行体检的具有完整资料的老年男性共1729人，平均年龄（73．94±6．77）岁。测量身高、体质量、腰围、血压、血糖、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、ApoA、ApoB、ApoA／ApoB。根据ApoA／ApoB四分位值将人群分为4组，以Logistic回归分析ApoA／ApoB与MS及其组分的关系。结果（1）中心性肥胖、高TG、低水平HDL-C、高血糖、MS患病率随着ApoA／ApoB降低而逐渐升高（P〈0．01）。（2）有代谢异常患者ApoA／ApoB水平较无代谢异常者低（P〈0．01）。（3）ApoA／ApoB水平随代谢异常组分增多而降低（P〈0．01）。（4）ApoA／ApoB下四分位组发生MS是ApoA／ApoB上四分位组的4．126倍（P〈0．01）。去除高血脂影响后，ApoA／ApoB下四分位组发生MS是ApoA／ApoB上四分位组的2．651倍（P〈0．01）。结论ApoA／ApoB与MS及其相关组分有密切的关系，MS、代谢异常者ApoA／ApoB较低。而低ApoA／ApoB也较易出现MS。ApoA／ApoB对MS的影响是独立于TC、TG、HDL-C、LDL-C之外的。

Relationship of ApoA/ApoB with metabolic syndrome and its components in elderly males

Objective To investigate the relationship of APOA/APOB with metabolic syndrome（MS） and its components in elderly males. Methods In this cross-sectional study, a total of 1729 old men （ mean age, 73.94 ± 6. 77 years） with complete data were enrolled. All participants＇ body height, weight, waist circumference, blood pressure, fasting plasma glucose, HDL-C, LDL-C, APOA, ApoB, APOA/ApoB were measured. Quartiles of concentration of APOA/ APOB were computed. Logistic regression model was used to estimate the relation between APOA/ApoB level and relative risks of MS. Results （ 1 ） With the decrease of the ApoA/ApoB, the incidence of central obesity, hyperglycemia, hypertriglyceridemia, low high density lipoprotein and MS increased（ P 〈 0. 01 ）. （2） APOA/APOB was lower in those with central obesity, hyperglycemia, hypertension, hypertriglyceridemia, low high density lipoprotein or MS than those without （P 〈 0. 01 ）. （3） APOA/APOB was increased with the increase of the number of MS components （P 〈 0. 01 ）. （4） The highest quartile of ApoA/ApoB was 1.57, and the lowest quartile of ApoA/ApoB was 1.09. Compared with the highest quartile of ApoA/ApoB, the lowest quartile of ApoA/ApoB had increased the relative risk of MS （4. 126 times, P 〈0. 01 ）. Excluding person who had abnormal TC ,TG,HDL-C ,LDL-C ,the lowest quartile of ApoA/ApoB still increased the relative risk of MS （2. 651 times, P 〈 0. 01 ）. Conclusions There is significant association between ApoA/ApoB and MS and its components in old men. ApoA/ApoB is lower in those with metabolic disorders. Persons with low ApoA/ApoB tend to have MS. ApoA/ApoB may affect the incidence of MS, which is independent of the effect of other lipids.