肝细胞癌NOS3和VEGF表达的临床意义

【目的】研究肝细胞癌组织中一氧化氮合酶3(NOS3)和血管内皮生长因子(VEGF)的表达及其临床意义。【方法】通过免疫组化的方法检测51例肝细胞癌组织NOS3和VEGF的表达。【结果】NOS3和VEGF在51例肝细胞癌组织中的阳性率分别为53%和63%；NOS3在复发组的阳性率明显高于无复发组(P<0.01)；VEGF在小肝癌组、门静脉癌栓组和2年内复发组的阳性率分别高于大肝癌组、无门静脉癌栓组和2年内未复发组(P<0.05)；肝细胞癌组织中NSO3和VEGF的表达呈正相关(P<0.001)。【结论】NOS3、VEGF与肝细胞癌门静脉癌栓形成和预后等生物学行为有密切关系。

Expression of Nitric Oxide Synthase 3 and Vascular Endothelial Growth Factor in Hepatocellular Carcinoma

To investigate the expression of nitric oxide synthase 3 (NOS3) and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC). The expression of NOS3 and VEGF were detected by immunohistochemistry in 51 cases of HCC. The positive of NOS3 and VEGF in HCC were 53% and 63%. The expression rate of NOS3 in the recurrent group was significantly higher than that in the non recurrent group (P<0.01). The expression rates of VEGF in the group with carcinoma embolus of portal vein and the recurrent group were significantly higher than those in the group without carcinoma embolus and non recurrent group (P<0.05). The expression of NOS3 was closely related with the expression of VEGF positively in HCC. [Conclusions] NOS3 and VEGF are related with the biological behavior of HCC closely.