疣毒净对复发性尖锐湿疣患者淋巴细胞凋亡调控蛋白的影响

目的 :　观察中药疣毒净系列制剂对复发性尖锐湿疣患者淋巴细胞凋亡调控蛋白的影响。方法 :　选择经疣毒净系列制剂治疗前、后复发性尖锐湿疣患者血液行淋巴细胞凋亡调控蛋白Bcl - 2、CD95 + 、CD95L的检测并与健康人群进行对照。结果 :　复发性尖锐湿疣患者治疗前后CD95 + 、CD95L表达水平高于健康对照组 ,Bcl- 2则低于健康对照组 (P<0 .0 5 ) ,而治疗前组CD95 + 、CD95L表达水平分别高于治疗后组 (P <0 .0 5 ) ,Bcl- 2则低于治疗后组 (P <0 .0 1)。结论 :　经疣毒净治疗后抗凋亡能力有明显提高

The influence of Youdujing on lymphocyte apoptosis - modulated protein in recurrent condyloma acuminatum

Objective: To determine the influence of lymphocyte apoptosis-modulated protein in the patients with recurrent condyloma acuminatum (CA) treated with Youdujing (YDJ). Methods: Apoptosis modulated proteins Bcl-2, CD95 + and CD95L were detected in the patients with recurrent CA before and after treatment with YDJ and compared with normal controls.Results: Before or after the treatment with YDJ, the expressions of CD95 + and CD95L was higher in patients with recurrent CA than that in normal controls while the expression of Bcl-2 was lower in the patients than that in normal controls (P<0.05). In addition, the expression of CD95 + and CD95L was higher before the treatment with YDJ than that after the treatment with YDJ (P<0.05), while the expression of Bcl-2 was higher after treatment than that before treatment (P<0.01). Conclusion : The ability of anti-apoptosis has significantly increased in the patients treated with YDJ.