苯扎贝特的相转移催化法合成 |
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引用本文: | 吴洁.苯扎贝特的相转移催化法合成[J].中国医药工业杂志,2008,39(9). |
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作者姓名: | 吴洁 |
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作者单位: | 淮阴工学院生化学院,江苏淮安,223001 |
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摘 要: | 对氯苯甲酰氯和对羟基苯乙胺反应制得N-(4-羟基苯乙基)-4-氯苯甲酰胺,再在相转移催化剂TEBA作用下、氢氧化钠溶液中加丙酮和氯仿反应制得降血脂药苯扎贝特,总收率约67%。
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关 键 词: | 苯扎贝特 高脂血症 相转移催化法 合成 |
Synthesis of Bezafibrate by Phase Transfer Catalysis |
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Authors: | WU Jie |
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Abstract: | Bezafibrate was synthesized from 4-chlorobenzoyl chloride and 4-hydroxyphenethylamine to give N-(4-hydroxyphenethyl)-4-chlorobenzamide followed by reaction with acetone and chloroform in the presence of TEBA in sodium hydroxide aqueous solution with an overall yield of about 67%. |
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Keywords: | bezafibrate hyperlipemia phase transfer catalysis synthesis |
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