乳腺癌患者手术治疗前后血清CA153、CA125、TSGF检测的临床意义

目的:探讨乳腺癌患者手术治疗前后血清CA153、CA125和TSGF水平的变化及意义.方法:应用放射免疫分析和生化法对36例乳腺癌患者进行了血清CA153、CA125和TSGF检测,并与35名正常健康人作比较.结果:手术治疗前血清CA153、CA125和TSGF水平非常显著地高于正常人组(P＜0.01),手术治疗后1个月皆已接近正常.手术治疗后6个月再测,未复发者仍属正常水平,而复发者又恢复至手术治疗前水平.结论:测定乳腺癌患者血清CA153、CA125和TSGF水平的变化对患者的治疗和预后均具有重要的临床价值.

Clinical Significance of Determination of Changes of Serum CA153, CA125 and TSGF Levels After Operation in Patients with Breast Cancer

Objective To study the clinical significance of changes serum CA153, CA125 and TSGF levels after operation in patients with breast cancer. Methods Serum CA153, CA125 and TSGF (with RIA) and serum TSGF levels (with biochemistry method) were measured in 36 patients with breast cancer both before and after operation as well as in 35 controls. Results Before operation, serum levels of serum CA153, CA125 and TSGF in the patients were significantly higher than those in the controls (P<0.01 ). One month after operation, all the levels were approaching normal. Six months later, the levels in the patients without recurrence remained normal, however, the levels in the 4 patients with recurrence returned to those before operation again. Conclusion Changes of serum CA153, CA125 and TSGF levels are closely related to the tumor burden and if levels were high after operation, may indicate the presence of recurrence.