颈椎病患者突出椎间盘周围的炎症反应及临床意义

目的：观察颈椎病患者突出椎间盘周同组织的病理表现，并探讨其临床意义。方法：79例颈椎病患者手术切除100个突出的椎间盘；取出间盘周围的绀织进行HE染色及免疫绀化染色。将染色结果结合其临床表现、影像学资料进行分析。结果：45个(45％)突出间盘周围的组织内可见血管增生、炎症细胞浸润：炎症组与无炎症组患者在病程、术后脊髓功能改善方面存在显著性差异；炎症反应与颈椎不稳定之间存在显著相关性。结论：(1)部分颈椎病患者突出椎间盘周围组织内存在慢性炎症反应，炎症浸润细胞多为单核-巨噬细胞及淋巴细胞；(2)颈椎不稳定可能是造成突出椎间盘周围组织内炎症反应的原因之一；(3)慢性炎症因素可能参与了颈椎病的发病。

Inflammation in the tissue adjacent to herniated cervical disc in patients with cervical spondylosis and its clinical meanings

Objective:To study the pathology of tissue adjacent to herniated cervical disc in patients with cervical spondylosis,and its clinical meanings.Method:79 patients were studied,and 100 discs and its adjacent tissue were obtained during operation.The 100 discs were used for histologic and immunohistochemical examination,and their clinical manifestations and images were studied.Result:45(45%) discs and its adjacent tissue showed proliferated small vessels and inflammatory cells.The inflammation were all in tissue adjacent to herniated discs.The disease course of patients with inflammation had significant difference with patients who had no inflammation;so did the spinal cord function improvement.Inflammation was significantly correlated with cervical instability.Conclusion:Patients with cervical spondylosis have inflammation in the tissue adjacent to herniated discs,and most of the inflammatory cells are macrophages and lymphocytes.Cervical instability may be one of the causes of inflammation in the herniated discs.Chronic inflammation may participate in pathogenesis of cervical spondylosis.