急性冠状动脉综合征患者的中性粒细胞与淋巴细胞比值分析

目的 探讨血中性粒细胞与淋巴细胞比值(NLR)在急性冠状动脉综合征(ACS)患者中的临床价值.方法 选择ACS患者267例,分为急性心肌梗死组(AMI组)152例及不稳定型心绞痛组(UA组)115例,入院后分别行冠状动脉造影术,并根据冠状动脉病变支数分组.选择有胸痛表现但冠状动脉造影为阴性的86例患者作为对照组.所有入选患者于入院24小时内采血测定白细胞(WBC)、中性粒细胞(N)、淋巴细胞(L)、超敏C反应蛋白(hs-CRP)、尿酸(UA)、肌酐(SCr)等指标,并计算N与NLR.比较各组之间各项指标的差异.结果 ACS患者的WBC、N、NLR、hs-CRP均高于对照组(P＜0.05);AMI组NLR高于对照组,6.49±4.01 vs 1.68±0.46(P＜0.05)和UA组,6.49±4.01 vs 2.68±1.49(P＜0.05).NLR随冠状动脉病变支数增加逐渐增高.NLR与WBC、L、N、UA及hs-CRP呈线性相关(r=0.656、-0.543、0.739、0.193、0.575,均P＜0.05).结论 NLR对ACS患者病情及冠状动脉病变支数判断有一定的临床价值.

Analysis on neutrophil to lymphocyte ratio in acute coronary syndrome patients

Objective To investigate the clinical value of the neutrophil to lymphocyte ratio（NLR） in patients with acute coronary syndrome（ACS）. Methods The study enrolled 267 ACS patients who were divided into acute myocardial infarction （AMI） group （ n = 152） and unstable angina pectoris （UA） group （ n = 115 ）. Coronary angiography was performed after admission and the patients were grouped according to the numbers of stenosed coronary artery. Eighty-six chest pain patients with negative coronary angiography were selected as control group. The blood was drawn for all patients within 24 hours after hospitalization, white blood cell（WBC）, neutrophil count（N）, lymphocyte（L）, high-sensitivity C reactive protein（hs-CRP）, uric acid（UA）, creatinine （SCr） and other indicators were measured and NLR was calculated. Each index was compared between groups. Results WBC,N,NLR,hs-CRP in ACS patients were higher than those of the control group（ P 〈0.05） ; NLR in AMI group was higher than in the control group,6.49±4.01 vs 1.68±0.46（ P 〈0.05） ,and NLR in AMI group was higher than in UA group,6.49±4.01 vs 2.68±1.49 （ P 〈0.05）. NLR increased gradually with the increase of numbers of stenosed coronary artery. NLR was correlated with WBC,L,N,UA and hs-CRP （ r = 0. 656, -0. 543,0. 739,0. 193,0. 575, all P 〈0.05）. Conclusion NLR has certain clinical value for the assessment of disease condition and the numbers of stenosed coronary artery in ACS patients.