Graves病合并糖耐量异常患者红细胞胰岛素受体变化的研究

目的：观察Graves病合并糖耐量异常（IGT，DM）红细胞胰岛素受体的改变。方法：用放射免疫分析法检测Graves病合并糖耐量异常组（简称Graves病组）与正常对照组的红细胞胰岛素高，低亲和力型受体（R1，R2）数目，并以相应的亲和常数K1，K2反映受体结合力的大小。结果：Graves病组空腹R1，R2，K1，K2均降低，但无统计学意义（P＞0．05），餐后2hR1下降，血糖，胰岛素均显著升高（P＜0．01），结论：Graves病合并糖代谢异常存在红细胞胰岛素高亲和力受体的异常。

CHANGES OF ERYTHROCYTE INSULIN RECEPTORS IN GRAVES DISEASE PATIENTS WITH ABNORMAL GLUCOSE TOLERANCE

Objective:To observe the changes of erythrocyte insulin receptors in Graves disease with abnormal glucose tolerance (IGT,DM).Methods:Insulin receptors (High-affinity type:R 1 and low-affinity type:R 2 ) in Graves disease patients with abnormal glucose tolerance (Graves group) and normal group were measured by radioimmunoassay technique. Both K 1 and K 2 were the indexes of the appetence for R 1 and R 2 accordingly. Results: Contrasting with normal group, both fasting R 1,R 2 and K 1,K-2 in Graves group decreased (P>0.05). R 1 ,plasma glucose,insulin of Graves group significantly decreased in postprandial 2h (P<0.01).Conclusion:The abnormality of erythrocyte high-affinity type insulin receptors were found in Graves disease with glucose metabolism disorder.