| 高效液相色谱法测定人血浆中兰索拉唑浓度 |
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| 引用本文： | 董福祥,胡玉荣,乔海灵.高效液相色谱法测定人血浆中兰索拉唑浓度[J].中国药房,2005,16(15):1155-1157. |
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| 作者姓名： | 董福祥 胡玉荣 乔海灵 |
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| 作者单位： | 1. 河南省人民医院药剂科,郑州市,450053
2. 郑州大学药学院,郑州市450052 |
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| 摘 要： | 目的:建立以高效液相色谱法测定人血浆中兰索拉唑浓度的方法。方法:9例健康男性志愿者单剂量口服兰索拉唑胶囊30mg,采用高效液相色谱法测定给药后不同时间兰索拉唑血药浓度,以3p97程序计算其药动学参数。结果:兰索拉唑检测浓度线性范围为0.05～4.00mg/L(r=0.9994),最低检测浓度为0.025mg/L,日内及日间RSD均<10%。结论:本方法灵敏、准确、稳定,适用于兰索拉唑血药浓度监测。
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| 关 键 词： | 兰索拉唑 高效液相色谱法 血药浓度 药动学 |
| 文章编号： | 1001-0408（2005）15-1155-03 |
| 收稿时间： | 2004-12-15 |
| 修稿时间： | 2005-03-30 |
Determination of Concentration of Human Plasma Lansoprazole by HPLC |
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| DONG Fuxiang,HU Yurong,Qiao Hailing.Determination of Concentration of Human Plasma Lansoprazole by HPLC[J].China Pharmacy,2005,16(15):1155-1157. |
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| Authors: | DONG Fuxiang HU Yurong Qiao Hailing |
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| Abstract: | OBJECTIVE:To establish HPLC method for the determination of human plasma concentration of Lansopraˉzole.METHODS:The human plasma concentrations of lansoprazole of9healthy volunteers were determined by HPLC at different time after administered with single oral dose of lansoprazole30mg and the pharmacokinetics parameters were calcuˉlated by the3p97program.RESULTS:Linear detection concentration range of lansoprazole was from0.05～4.00mg/L(r=0.9994).The minimum detection concentration for lansoprazole was0.025mg/L.Both the intra-day and inter-day RSD we_ re less than10%.CONCLUSION:The method is sensitive,accurate,stable and suitable for blood concentration monitoring of lansoprazole. |
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| Keywords: | Lansoprazole HPLC Blood concentration Pharmacokinetics |
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