新辅助内分泌治疗配合腹腔镜手术治疗高危前列腺癌的疗效及对控尿功能的影响

目的:观察新辅助内分泌治疗配合腹腔镜手术治疗高危前列腺癌的疗效及对控尿功能的影响。方法:选取收治的86例高危前列腺癌患者作为研究对象,遵循随机、均等原则分为对照组与观察组,其中对照组行腹腔镜前列腺癌根治术,观察组在对照组基础上配合新辅助内分泌治疗。观察两组术中及术后指标、并发症发生率、生化复发率。结果:观察组手术时间、术中出血量高于对照组(P0.05);观察组下床活动时间、住院时间、留置导尿管时间、肠功能恢复时间短于对照组(P0.05);观察组并发症发生率(13.95%)低于对照组(32.56%,P0.05);术后3个月、6个月,观察组控尿率高于对照组(P0.05);术后1年、2年,观察组生化复发率低于对照组(P0.05)。结论:新辅助内分泌治疗联合腹腔镜前列腺癌根治术治疗高危前列腺癌可有效降低并发症发生率,改善控尿功能,但术前需对患者病情进行评估。

The therapeutic effect of neo-adjuvant hormone therapy combined with laparoscopic surgery in the treatment of high-risk prostate cancer and its effect on urinary continence

Objective:To observe the therapeutic effect of neo-adjuvant hormone therapy combined with laparoscopic surgery in the treatment of high-risk prostate cancer and the effect on urinary continence.Methods:Eighty-six patients with high-risk prostate cancer were selected and randomly and equally divided into control group and observation group.Control group was treated by laparoscopic radical prostatectomy,and observation group added neo-adjuvant hormone therapy on the basis of the control group.The intraoperative and postoperative indexes,complication incidence,biochemical recurrence rate were observed in the two groups.Results:The operation time and intraoperative bleeding in the observation group were significantly higher than the control group (P ＜ 0.05).Ambulation time,hospital stay,indwelling catheter time and intestinal function recovery time in observation group were significantly less than those in the control group (P ＜ 0.05).The complication incidence of the observation group (13.95％) was significantly lower than that of the control group (32.56％,P ＜ 0.05).Urinary continence rate of the observation group in 3 months and 6 months after surgery was significantly higher than that of the control group (P ＜ 0.05).Biochemical recurrence of observation group in 1 year and 2 years after surgery was significantly lower than that of the control group (P ＜ 0.05).Conclusions:Neo-adjuvant hormone therapy combined with laparoscopic radical prostatectomy can effectively reduce the complications in high-risk prostate cancer and improve urinary continence,but is in need of evaluation of patients before operation.