放射治疗并口服化学药物治疗食管癌疗效观察

目的探讨食管癌放射治疗同步口服化学抗癌药物治疗的作用效果。方法采用放射治疗加口服红豆衫胶囊治疗食管癌患者50例(联合组)与单纯放疗50例(单放组)进行临床疗效观察比较。结果观察病例随访3年,比较两组1、2、3年生存率,联合组分别为76%(3850)、68%(3450)和58%(2950),单放组分别为56%(2850)、44%(2250)和38%(1950),联合组高于单放组,两组间比较有统计学意义(P<005)。临床症状改善情况,联合组好于单放组。结论放射治疗与口服红豆杉胶囊同步治疗食管癌,不增加放、化疗副反应,能提高患者肿瘤消退率和近期生存率。

Therapeutic effect of radiotherapy synchronized with oral Hong Dou Shan chemotherapy in treatment of esophageal carcinoma

Objective To observe the therapeutic effect and short-term reaction of radiotherapy synchronized with oral Hong Dou Shan chemotherapy for treatment of esophageal carcinoma. Methods From 1997 to 2001,50 patients with esophageal carcinoma were treated with radiotherapy synchronized with Hong Dou Shan capsule chemotherapy(group A)and another 50 such patients treated with radiotherapy alone(group B).Clinical therapeutic effects was compared between these two groups. Results The patients were followed-up for three years.The 1-,2-,and 3-year survival rates were 76%(38/50),68%(34/50) and 58%(29/50) in group A and 56% (28/50),44%(22/50) and 38% (19/50) in group B,respectively(P<0.05).Improvement of the clinical symptoms was more evident in group A than in group B. Conclusion Radiotherapy synchronized with Hong Dou Shan capsule chemotherapy for treatment of esophageal caricnoma could increase the tumor extinctive rate and short-term survival rate without increase of adverse reactions.Hong Dou Shan is one of the ideal chemical drugs when synchronized with radiotherapy for treatment of esophaguseal carcinoma.;