Cytomegalic adrenal hypoplasia with pituitary cytomegaly

Summary A case of cytomegalic congenital adrenal hypoplasia (C.C.A.H.) is reported with similar cytomegalic changes in the hypophysis. In this case the pituitary gland was small as were the thyroid and testes. The various groups of patients with C.A.H. are presented. Associated pituitary cytomegaly does not appear to have been previously described, and this association between the adrenal and pituitary changes is discussed. It is suggested that the adrenal cytomegaly is the result of overstimulation by the pituitary and the similar change in the latter may be the result of overstimulation of a hypoplastic organ.