Transient Cerebral Ischemia and Brain Serotonin: Relevance to Migraine |
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| Authors: | Dr. K.M.A. Welch Dr. Robert Gaudet Dr. T.P.F. Wang Dr. Eva Chabi |
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| Affiliation: | Laboratory of Clinical and Experimental Cerebral Metabolism, Baylor-Methodist Center for Cerebrovascular Research, and Department of Neurology, BayIor College of Medicine, Houston, Texas 77030 |
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| Abstract: | SYNOPSIS
Central pain supersensitivity related to depletion of serotonin in the central nervous system has been postulated as a mechanism for migraine. In the present study, transient cerebral ischemia in an animal preparation caused depletion of central nervous system serotonin. Ischemia associated with the prodromal phase of migraine must, therefore, be considered as a possible cause of altered central nervous system serotonin metabolism, possibly leading to increased pain sensitivity |
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