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Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome |
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| Authors: | S. Roy C. K. Datta A. Hirano N. R. Ghatak H. M. Zimmerman |
| Affiliation: | (1) Division of Neuropathology, Department of Pathology, Montefiore Hospital and Medical Center, 111 East 210th Street, 10467 Bronx, New York, USA;(2) Albert Einstein College of Medicine, 10467 Bronx, New York |
| Abstract: | Summary The neurofibrillary tangles found in the neurons of a case of Steele-Richardson-Olszewski syndrome were studied by electron microscopy. Both the flame-shaped and globose type of tangles were present. The neurofibrillary tangles were composed of bundles of straight tubules measuring approximately 150 Å in diameter. This ultrastructural appearance of the tangles in Steele-Richardson-Olszewski syndrome is different from the appearance of tangles found in other neurological disorders and is probably indicative of intraneuronal accumulation of a new type of fibrous protein.This investigation received financial support from the World Health Organization. |
| Keywords: | Steele-Richardson-Olszewski Syndrome Progressive Supranuclear Palsy Neurofibrillary Tangles Electron Microscopy |
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