| 基因nm23-H1和TGVβ1在人体食管癌中的表达及其临床病理关系的意义 |
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| 引用本文： | 张明伟,王芳,张雷,尚宪荣. 基因nm23-H1和TGVβ1在人体食管癌中的表达及其临床病理关系的意义[J]. 临床和实验医学杂志, 2008, 7(8): 43-44 |
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| 作者姓名： | 张明伟 王芳 张雷 尚宪荣 |
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| 作者单位： | [1]山东省莱芜市莱城区人民医院病理科,山东莱芜271100 [2]北京中医药大学东方医院胸外科,北京100078 |
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| 摘 要： | 目的探讨转移抑制基因nm23-H1及转化生长因子β1（TGFβ1）基因在人食管癌（EC）中的表达水平及其临床病理关系。方法应用免疫组化方法对56例人食管癌组织中转移抑制基因nm23～H1及TGFβ1基因表达蛋白水平进行研究。结果nm23-H1和TGFβ1表达水平与食管的TNM分期、细胞分化程度及食管癌的转移有密切关系（P〈0．05）。结论nm23-H1、TGFβ1基因表达水平同时降低，预示食管癌的转移和预后不良。
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| 关 键 词： | 食管癌 nm23-H1基因TGFβ1 基因 转移 |
The expressions of nm23 - H1 and TGFβ1 in human esophageal cancer and their clinical and pathological correlation |
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| Affiliation: | ZHANG Ming - wei, WANG Fang, ZHANG Lei, et al. (Department of pathology, The People＇s Hospial of Laicheng Region in Laiwu, Laiwu Shandong 271100, China) |
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| Abstract: | Objective To investigate the expressions of nm23 - H1 metastasis suppressor gene and TGFβ1 gene in human esophageal cancer, as well as their clinical and pathological correlation. Methods The expressions of nm23 - H1 metastasis suppressor gene and TGFβ1 gene in the 56 human esophageal carcinoma specimens were investigated by immunohistochemistry. Results The expression levels of nm23 - H1 and TGFβ1 were closely correlated to TNM staging degree of differentiation and metastasis of esophageal cancer （ P 〈0.05 ）. Esophageal cancer with metastasis to lymph nodes had a siguificantly lower expression level of TGFβ1 than those without such metastasis （ P 〈 0. 05） . Condusion Both nm23 - H1 and TGFβ1 take part in the regulation of the process of the genesis, development, and metastasis of esophageal cancer. A simultaneous decrease in the expression of both genes suggests metastasis and a poor prognosis. |
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| Keywords: | Esophageal cancer Nm23- H1 gene TGFβ1 gene Metastasis |
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