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山梗菜生物碱类化合物的ESI-MSn研究
引用本文:王秀丽,孙佳明,宋洋,张辉. 山梗菜生物碱类化合物的ESI-MSn研究[J]. 中国中药杂志, 2008, 33(13): 1572-1574
作者姓名:王秀丽  孙佳明  宋洋  张辉
作者单位:长春中医药大学,中医药与生物工程研发中心,吉林,长春,130017
摘    要:目的:对山梗菜中生物碱类化合物进行定性分析。方法:利用固相萃取技术(SPE)、电喷雾多级串联质谱技术(ESI-MSn)对山梗菜中生物碱类化合物进行定性分析。结果:初步确定了山梗菜中的2个生物碱结构分别是异山梗菜酮碱和8,10-二乙基山梗二酮,并根据其在正离子条件下表现出的特征质谱行为,提出了山梗菜中生物碱类化合物可能的电喷雾质谱碎裂规律。结论:固相萃取技术、电喷雾多级串联质谱技术能够快速简便地对山梗菜中生物碱类化合物进行定性分析。

关 键 词:山梗菜  生物碱  固相萃取  电喷雾多级串联质谱
收稿时间:2007-10-22

Studty on alkaloids in Lobelia sessilifolia by ESI-MSn
WANG Xiu -li; SUN Jia-ming; SONG Yang; ZHANG Hui. Studty on alkaloids in Lobelia sessilifolia by ESI-MSn[J]. China Journal of Chinese Materia Medica, 2008, 33(13): 1572-1574
Authors:WANG Xiu -li   SUN Jia-ming   SONG Yang   ZHANG Hui
Affiliation:Development Center of Traditional Chinese Medicine and Bioengineering, Changchun University of Traditional Chinese Medicine, Changchun 130117, China.
Abstract:Objective: To make qualitative analysis on alkaliod in Lobelia sessilifolia. Method: The ESI-MSn method was used for qualitative analysis. Result: The structures of two alkaliods in plant extract of L. sessilifolia were successfully analyzed and identified as norlobelanine and 8, 10-diethyllobelidione by electrospray ionization multistage mass spectrometry in positive mode. Then the fragmentation mechanisms were explored. Conclusion: SPE and ESI-MSn could simply and rapidly provide qualitative examination of alkaliods in L. sessilifolia.
Keywords:Lobelia sessilifolia   alkaliod   SPE   ESI-MSn
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