Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol |
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| Authors: | Robert E. Royer Ray G. Mills Lorraine M. Deck Gregory J. Mertz David L. Vander Jagt |
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| Affiliation: | Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131. |
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| Abstract: | Gossypol (I) and its derivatives gossylic nitrile-1,1'-diacetate (II), gossylic iminolactone (III) and gossylic lactone (IV) inhibit the replication of human immunodeficiency virus type 1 in vitro in the order III greater than I greater than II,IV, indicating that derivatives of gossypol can retain antiviral activities. All of the derivatives are less cytotoxic than gossypol. |
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| Keywords: | gossypol derivatives HIV-1 antiviral drugs |
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