青蒿琥酯对小鼠实验性肝损伤的保护作用

研究抗疟新药青蒿琥酯(Art)对扑热息痛(AAP)和CCl_4引起的小鼠急性肝损伤的保护作用。实验结果证实,预先给小鼠ip Art200mg/kg,或100mg/kg共3次,其血清GPT和肝脏病变均明显低于对照组;并能降低AAP中毒小鼠的死亡率,对抗AAP所致小鼠早期肝糖元下降。此外,Art尚能显著缩短小鼠戊巴比妥钠睡眠时间,提示它可能具有诱导肝脏药物代谢酶作用。

STUDIES ON THE PROTECTIVE EFFECTS OF ARTESUNATE AGAINST EXPERIMENTAL LIVER INJURIES IN MICE

Artesunate ( Art ) is one of the derivatives of Qinghaosu ( Arte-misinin ), an effective and nontoxic new drug from the traditional Chinese medicine Qinghao ( Artemisia annua L. ).We observed a striking protection of Art against acute liver inju-ries induced by Acetaminophen(AAP)and CC14 in mice. The elevated serum transminase levels and liver lesions were reduced by Art given 100mg/kg or 200mg/kg ip to mice. Art also inhibited AAP-induced decrease of liver glycogen and reduced mortality in AAP-treated mice. In addition, Art markedly decreased the duration of the hypnosis of sodium pen tobarbital in mice, suggesting a stimulatory effect of Art on hepatic-metabolizing enzymes.