| Anchanling reduces pathology in a lactacystin-induced Parkinson’s disease model |
| |
| 作者姓名： | Andrew C.J.Huang |
| |
| 作者单位： | Larry Hillblom Islet Research Center,David Geffen Medicine |
| |
| 基金项目： | supported by the National Natural Science Foundation of China (Influence of Anchanling on endoplasmic reticulum stress and ubiquitin-proteasome system in PD model), No. 30772757 |
| |
| 摘 要： | A rat model of Parkinson’s disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when compared with Parkinson’s disease model rats, tyrosine hydroxylase expression was increased, α-synuclein and ubiquitin expression was decreased, substantia nigra cell apoptosis was reduced, and apomorphine-induced rotational behavior was improved. Results suggested that Anchanling can ameliorate Parkinson’s disease pathology possibly by enhancing degradation activity of the ubiquitin-proteasome system.
|
| 关 键 词： | Parkinson’s disease Anchanling ubiquitin-proteasome system α-synuclein tyrosine hydroxylase cell apoptosis |
| 收稿时间： | 2011-06-02 |
| 本文献已被 CNKI 等数据库收录！ |
|
