Anchanling reduces pathology in a lactacystin-induced Parkinson’s disease model |
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作者姓名: | Andrew C.J.Huang |
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作者单位: | Larry Hillblom Islet Research Center,David Geffen Medicine |
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基金项目: | supported by the National Natural Science Foundation of China (Influence of Anchanling on endoplasmic reticulum stress and ubiquitin-proteasome system in PD model), No. 30772757 |
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摘 要: | A rat model of Parkinson’s disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when compared with Parkinson’s disease model rats, tyrosine hydroxylase expression was increased, α-synuclein and ubiquitin expression was decreased, substantia nigra cell apoptosis was reduced, and apomorphine-induced rotational behavior was improved. Results suggested that Anchanling can ameliorate Parkinson’s disease pathology possibly by enhancing degradation activity of the ubiquitin-proteasome system.
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关 键 词: | Parkinson’s disease Anchanling ubiquitin-proteasome system α-synuclein tyrosine hydroxylase cell apoptosis |
收稿时间: | 2011-06-02 |
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