The external secretory activity of the pancreas after wide resection of the proximal division of the small intestine

Summary Experimental material presented was obtained on 2 dogs with a fistula according to Bakuradze and on one animal with the pancreatic duct exteriorized according to Pavlov. After the establishment of the normal secretion in response to the main food stimuli (100 gm of meat and 200 ml of milk) the dogs were subjected to an extensive resection (65–70%, 155–190 cm) of the superior portions of the small intestine. As shown, secretion in response to 100 gm of meat was considerably increased in all the 3 dogs; the concentration of the enzymes (amylase and trypsin) per 1 ml of the juice remained almost unchanged, varying within the range of preoperative values. However, the total amount of the enzyme units is markedly increased in connection with the increased amount of the juice. Secretion in response to 200 ml of milk was reduced in 2 dogs and increased in one. The concentration of the enzymes remained within the range of the initial values. The data obtained demonstrated that extensive intestinal resection caused mainly an increased pancreatic juice secretion in response to food stimuli, which could be regarded as a compensatory phenomenon.(Presented by Active Member AMN SSSR V. V. Parin) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 53, No. 4, pp. 57–60, April, 1962